Lab Mission: To create an enjoyable and rewarding learning environment through innovative and productive research in molecular virology, and to facilitate trainees’ career development.
Dr. Wu’s lab studies the molecular and cellular mechanisms of HIV replication, virus interaction with host factors, and antiviral innate immunity. The lab focuses on the mechanisms of HIV restriction by the host protein SAMHD1. We aim to further understand how SAMHD1 modulates HIV replication and antiviral innate immune responses in primary myeloid and CD4+ T cells. We also investigate the mechanisms by which RNA modifications regulate HIV gene expression and innate immune responses to viral infection. Our basic studies aim to facilitate the development of more effective interventions against HIV infection and transmission.
Graduate student and postdoc positions are available in the Wu Lab,